Forty-four patients with chronic or recurrent candidiasis of the dermis, mucous membranes, or both, have been studied in relation to associated diseases. Thirty-one patients (Group I) had at least one associated disease. Thirteen (Group II) had only candidiasis. Neonates with oral moniliasis, children with chronic debilitation, and children receiving antibiotics were eliminated from the study. Idiopathic hypoparathyroidism was the most common associated disease of the patients in Group I (26 of 31 patients). Addison's disease also was common (14 of 31 patients). Hypothyroidism, alopecia, cirrhosis, pernicious anemia, and primary gonadal failure also occurred. Evidence for subclinical disease of the thyroid, adrenal cortex, and gastric mucosa, as reflected by tissue specific antibodies, was common in patients with candidiasis. Anti-kidney antibodies also were found in 18 patients, but their significance is unclear. No etiological relationship between the candidiasis and the associated diseases could be demonstrated.
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Blizzard et al. (1968) studied this question.