What question did this study set out to answer?

To evaluate whether serum leucine-rich alpha-2 glycoprotein reflects disease activity more effectively than serum calprotectin in children with inflammatory bowel disease.

March 7, 2023Journal of Gastroenterology and HepatologyOpen Access

Serum leucine‐rich alpha‐2 glycoprotein and calprotectin in children with inflammatory bowel disease: A multicenter study in Japan

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To evaluate whether serum leucine-rich alpha-2 glycoprotein reflects disease activity more effectively than serum calprotectin in children with inflammatory bowel disease.
Multicenter study conducted across pediatric medical centers in Japan.
Evaluated pediatric patients diagnosed with inflammatory bowel disease, including Crohn's disease.
Assessed and compared circulating levels of serum leucine-rich alpha-2 glycoprotein and serum calprotectin against clinical disease activity.
Serum leucine-rich alpha-2 glycoprotein tracks disease activity more reliably than serum calprotectin across pediatric inflammatory bowel disease cases.
The superiority of serum leucine-rich alpha-2 glycoprotein over serum calprotectin is especially marked in pediatric patients with Crohn's disease.

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Implication

Multicenter study finds leucine-rich alpha-2 glycoprotein reflects disease activity better than calprotectin in pediatric inflammatory bowel disease, indicating superior diagnostic utility.

Cite This Study

Yasuda et al. (2023) studied this question.

synapsesocial.com/papers/69dc6fc5cdb4abb1d713342d https://doi.org/10.1111/jgh.16166

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Implication

Multicenter study finds leucine-rich alpha-2 glycoprotein reflects disease activity better than calprotectin in pediatric inflammatory bowel disease, indicating superior diagnostic utility.

Serum leucine‐rich alpha‐2 glycoprotein and calprotectin in children with inflammatory bowel disease: A multicenter study in Japan

Key Points

Discussion

Implication

Cite This Study

Serum leucine‐rich alpha‐2 glycoprotein and calprotectin in children with inflammatory bowel disease: A multicenter study in Japan

Key Points

Discussion

Implication

Cite This Study

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