Why the study?
Does discontinuing or not adhering to aspirin worsen prognosis in patients at risk for coronary artery disease?
Does discontinuing or not adhering to aspirin worsen prognosis in patients at risk for coronary artery disease?
Discontinuing aspirin in patients at moderate-to-high risk for CAD is associated with adverse prognostic implications and should only be done when bleeding risk clearly outweighs atherothrombotic risk.
Aspirin discontinuation or non-adherence warrants extreme caution in moderate-to-high CAD risk unless bleeding clearly predominates; confirms adverse prognosis and extends adherence guidance.
Non-compliance or withdrawal of aspirin treatment has ominous prognostic implication in subjects with or at moderate-to-high risk for CAD. Aspirin discontinuation in such patients should be advocated only when bleeding risk clearly overwhelms that of atherothrombotic events.
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Biondi‐Zoccai et al. (2006) studied this question.
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