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April 13, 2026Respiratory Care1 citations

Paradoxical Bronchoconstriction following Inhalation of Isoetharine Aerosol: A Case Report

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TWTheodore J. WitekESE Neil SchachterEZEugenia Zuskin

Key Points

  • To investigate a paradoxical bronchospastic response in a female asthmatic after inhaling isoetharine.
  • Reported case of a 41-year-old woman with asthma.
  • Administered isoetharine aerosol via metered-dose inhaler.
  • Conducted placebo analysis using carrier solution without bronchodilator.
  • Patient exhibited bronchoconstriction after isoetharine inhalation.
  • Analysis indicated the reaction might be related to the carrier solution components.
  • Highlights the need to consider alternatives in cases of paradoxical responses.

Abstract

A 41-year-old asthmatic woman appeared to have a paradoxical (bronchospastic) response to isoetharine aerosol from a metered-dose inhaler. Analysis of her response to a placebo preparation consisting of the carrier solution without the bronchodilator suggests that her adverse reaction was due to one of the components of the carrier solution. This explanation should be considered in any subject demonstrating a paradoxical response to a bronchodilator from an inhaler.

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Cite This Study

Witek et al. (1987) studied this question.

synapsesocial.com/papers/69dc874a3afacbeac03e9b0dhttps://doi.org/10.1177/194336548703200105
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