Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma

Key Points

• The research aims to determine the effectiveness of jointly inhibiting Cdk4/Cdk6 and BETs in osteosarcoma, regardless of RB status.
• In vitro analysis of osteosarcoma cell lines
• Application of Cdk4/Cdk6 and BET inhibitors
• Assessment of cell proliferation and survival
• Inhibition of Cdk4/Cdk6 and BETs significantly reduced osteosarcoma cell proliferation
• Effects were observed regardless of RB status in the tested cell lines