Retrospective cohort study identifies risk factors and biomarkers for ventilator-associated pneumonia in critically ill patients, suggesting potential clinical implications.
Key Points
This study aims to identify risk factors and biomarkers associated with ventilator-associated pneumonia in critically ill patients on prolonged mechanical ventilation.
Retrospective cohort study design
Inclusion of 267 adult ICU patients on ventilation for over 48 hours
Data collection on demographics, clinical characteristics, laboratory markers, and microbiological profiles
Statistical analysis using Mann–Whitney U test, chi-square test, and multivariable binary logistic regression
83.1% of patients developed ventilator-associated pneumonia
VAP was significantly correlated with prolonged ventilation duration (p = 0.016)
Higher C-reactive protein and white blood cell counts were independent predictors of VAP
Higher CRP was linked to decreased odds of death in the mortality model (aOR = 0.968; 95% CI: 0.941–0.996)