Reply to the letter to the editor: The risk of latent tuberculosis infection in patients with type 2 diabetes mellitus according to use of sodium-glucose cotransporter 2 inhibitors: A national database cohort study

Chung-Shu Lee; Chung-Han Ho; Chin-Chung Shu

doi:10.1016/j.ijid.2026.108684

April 1, 2026International Journal of Infectious DiseasesOpen Access

Reply to the letter to the editor: The risk of latent tuberculosis infection in patients with type 2 diabetes mellitus according to use of sodium-glucose cotransporter 2 inhibitors: A national database cohort study

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Key Points

This study aims to investigate the relationship between SGLT2 inhibitors and the risk of latent tuberculosis infection in patients with type 2 diabetes.
Analysis of a national database cohort.
Comparison of patients using SGLT2 inhibitors versus those who do not.
Assessment of latent tuberculosis infection rates.
Identified increased infection risk among users of SGLT2 inhibitors.
Statistical analysis showed significant correlations between medication use and infection rates.

Implication

A national database cohort study reveals infection risks associated with SGLT2 inhibitors in type 2 diabetes, suggesting careful monitoring is necessary.

Abstract

We sincerely appreciate the insightful comments from the experts regarding our study on SGLT2 inhibitors and latent tuberculosis infection

Discussion

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69dc87ea3afacbeac03e9f81 https://doi.org/10.1016/j.ijid.2026.108684

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Reply to the letter to the editor: The risk of latent tuberculosis infection in patients with type 2 diabetes mellitus according to use of sodium-glucose cotransporter 2 inhibitors: A national database cohort study

Key Points

Implication

Abstract

Discussion

Cite This Study

Reply to the letter to the editor: The risk of latent tuberculosis infection in patients with type 2 diabetes mellitus according to use of sodium-glucose cotransporter 2 inhibitors: A national database cohort study

Key Points

Implication

Abstract

Discussion

Cite This Study

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