This research demonstrates that excitability assessments can detect early pathology in hand muscles, suggesting earlier ALS diagnosis.
Disturbances to nerve excitability are similar across the split hand muscles at the time of ALS diagnosis. These occurred prior to motor unit loss and traditional EMG changes. Combining excitability and motor unit parameters in the lateral hand can identify early pathology and potentially lead to earlier diagnosis.
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Hodgson et al. (2026) studied this question.
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