The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome

Key Points

• To evaluate the relationship between APOE ε4 carriership and amyloid positivity using a blood test in individuals with Down syndrome.
• Conducted a blood test for proteomic biomarkers
• Examined amyloid positivity in asymptomatic adults with Down syndrome
• Analyzed the influence of APOE ε4 status on test results
• Blood tests effectively identified amyloid positivity in adults with Down syndrome
• Findings were relevant regardless of the presence of APOE ε4
• Results support potential use in clinical triage and monitoring