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Non-trauma settings show that low titer group O whole blood is safe and effective for patients with gastrointestinal and cardiovascular bleeding, suggesting an alternative to component therapy.
In non-trauma settings, LTOWB was most commonly utilized in patients with gastrointestinal and cardiovascular bleeding. LTOWB is a safe alternative to component therapy in non-trauma adult populations. However, additional studies are needed to focus on efficacy and clinical outcomes in non-trauma patients that receive LTOWB for severe hemorrhage.
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Bordas et al. (2026) studied this question.
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