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April 13, 2026Angewandte Chemie International Edition0 citationsOpen Access

Two-Dimensional Infrared Spectroscopy Identifies Bridging CO Ligands in [FeFe] Hydrogenase...

Two‐Dimensional Infrared Spectroscopy Reveals the Presence of a Bridging CO Ligand in Two Catalytic Intermediates of FeFe Hydrogenase

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Authors

CBCornelius C. M. BernitzkyMVMathesh VaithiyanathanMLManon T. Lachmann

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Overview

Two-dimensional infrared spectroscopy reveals bridging CO ligands in catalytic intermediates of [FeFe] hydrogenases, indicating their relevance for hydrogen conversion.

Key Points

  • To investigate the structural differences in catalytic intermediates of [FeFe] hydrogenases and determine the presence of bridging CO ligands.
  • Utilized two-dimensional infrared (2D IR) spectroscopy to analyze the states HredH+ and HsredH+.
  • Compared spectra to identify the presence of a bridging CO ligand in the intermediates.
  • Characterized the active site structure of [FeFe] hydrogenases during hydrogen conversion.
  • Demonstrated the presence of a bridging CO ligand (µCO) in both HredH+ and HsredH+ states.
  • Established these states as reduced [Fe(I)Fe(I)]H centres, contradicting previous models suggesting they were oxidized.
  • Provided insights into the catalytic mechanism, suggesting these intermediates are crucial for hydrogen conversion.
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Cite This Study

Bernitzky et al. (2026) studied this question.

synapsesocial.com/papers/69dc892e3afacbeac03eaec5https://doi.org/10.1002/anie.2628759
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  1. 1Two‐Dimensional Infrared Spectroscopy Reveals the Presence of a Bridging CO Ligand in Two Catalytic Intermediates of [FeFe] Hydrogenase2026
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  4. 4A Non‐Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]‐Hydrogenase Maturation2026
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