Why the study?
Is Leukocyte Telomere Length associated with biomarkers of cardiovascular disease risk in US adults?
Is Leukocyte Telomere Length associated with biomarkers of cardiovascular disease risk in US adults?
Leukocyte telomere length is associated with multiple cardiovascular risk factors, particularly adiposity, supporting its role as a biomarker of cardiovascular aging.
LTL associations with adiposity and biomarkers do not support clinical use; leaves open its value for cardiovascular risk prediction.
LTL is most strongly associated with adiposity, but is also associated with biomarkers across several physiological systems. LTL may thus be a predictor of cardiovascular disease through its association with multiple risk factors that are physiologically correlated with risk for development of cardiovascular disease. Our results are consistent with LTL being a biomarker of cardiovascular aging through established physiological mechanisms.
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Rehkopf et al. (2016) studied this question.
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