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April 17, 2023Clinical Cancer Research44 citations

Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer

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FBFélix Blanc‐DurandRTRoseline TangMPMargaux Pommier

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Abstract

Patients with ovarian cancer with high levels of BRCA1 hypermethylation are very likely to have high GIS and therefore represent good candidates for PARPi treatment. These results may be highly relevant to other tumor types for HRD prediction. See related commentary by Garg and Oza, p. 2957.

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Cite This Study

Blanc‐Durand et al. (2023) studied this question.

synapsesocial.com/papers/69dcace47873f5f05b1338a3https://doi.org/10.1158/1078-0432.ccr-22-3328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Variations in DNA Methylation Patterns During the Cell Cycle of HeLa Cells2007 · 76 citations
  2. 2Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries2018 · 88,117 citations
  3. 3BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients – A study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD)2014 · 104 citations
  4. 4Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial2017 · 1,888 citations
  5. 5Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2)2021 · 208 citations