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August 15, 2018British Journal of Cancer41 citationsOpen Access

BRCA1 and BRCA2 mRNA-expression prove to be of clinical impact in ovarian cancer

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ITIrina TsibulakVWVerena WieserCDC Degasper

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Abstract

Our findings may reflect higher platinum-sensitivity due to reduced capacity of DNA damage repair in tissues with low BRCA1/2-expression. In this context, especially in BRCA-wildtype cancers both parameters could also be potential predictors for PARP-sensitivity.

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Tsibulak et al. (2018) studied this question.

synapsesocial.com/papers/69dcace47873f5f05b1338a8https://doi.org/10.1038/s41416-018-0217-4
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Also Consider

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  1. 1Index for rating diagnostic tests1950 · 11,746 citations
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