This study provides the first direct evidence of increased sympathetic nerve activity in advanced pulmonary artery hypertension.
Sympathetic modulation merits therapeutic exploration in advanced PAH; extends prior indirect evidence via first direct recordings.
We report for the first time direct evidence of increased sympathetic nerve traffic in advanced PAH. Sympathetic hyperactivity in PAH is partially chemoreflex mediated and may be related to disease severity.
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Velez‐Roa et al. (2004) studied this question.
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