Early screening model for mild cognitive impairment based on resting-state functional connectivity: a functional near-infrared spectroscopy study

Figures

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  Fig. 1. The arrangement of measuring channels. Each ball represented a channel (CH), and the color indicated which region the channel belongs to. The nine ROIs were as follow: LPF = left prefrontal lobe; RPF = right prefrontal lobe; LT = left temporal lobe; P = superior parietal lobe; RT = right temporal lobe; LIP = left inferior parietal lobe; RIP = right inferior parietal lobe; LO = left occipital lobe; and RO = right occipital lobe.

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  Fig. 2. The inter-group differences in whole-brain mean functional connectivity. Black and grey points represent the HC and MCI groups, respectively. Asterisk indicates an extremely significant difference (**p<0.01).

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  Fig. 3. Regional differences in functional connectivity. Red lines indicate significant inter-group differences in the regional connection.

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  Fig. 4. (a) The ROC curves of the top six long-range connections in ascending order: RPF-RO (orange), RPF-LIP (purple), LPF-LO (blue), RPF-P (green), LPF-P (black), and RPF-LO (red). (b) The inter-group differences in the top six ROI-based functional connections. The color settings of the connections are consistent with (a). Circles and triangles represent the HC and MCI groups, respectively. Asterisk indicates an extremely significant difference (**p<0.01).

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  Fig. 5. (a) Channel-based connections with inter-group differences (*p<0.05). (b) Connections with highly significant difference (****p<0.01).