Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension

Agnieszka Korolczuk; Jerzy Bełtowski

doi:10.2174/1381612823666170124114524

February 23, 2017Current Pharmaceutical Design

Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension

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Key Points

To review the dual beneficial and detrimental roles of progranulin across obesity-related cardiometabolic pathologies.
Narrative synthesis of clinical evidence evaluating progranulin activity in metabolic disorders.
Assessment of associations between progranulin levels and diabetes, hyperlipidemia, hypertension, and atherosclerosis.
Progranulin exhibits both protective and detrimental biological actions in metabolic disease pathways.
Existing clinical evidence remains inconclusive, requiring prospective studies to define progranulin's precise pathogenic or therapeutic role in obesity-associated conditions.

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Implication

Highlights dual effects of progranulin across metabolic disorders, indicating a need for prospective clinical trials.

Abstract

Progranulin has both detrimental and beneficial effects. More clinical studies including prospective ones are needed to clarify the role of progranulin in obesity-associated pathologies such as diabetes, hyperlipidemia, hypertension and atherosclerosis.

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Korolczuk et al. (2017) studied this question.

synapsesocial.com/papers/69dcc2d2f3d3790cb7133a1f https://doi.org/10.2174/1381612823666170124114524

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Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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