The study identifies that HEV RNA triggers an interferon-related antiviral response via IRF3/7 and the JAK-STAT cascade, elucidating HEV-host interactions.
Should not yet change HEV management; leaves open IRF3/7-JAK-STAT targeting in human studies.
HEV infection elicits an active IFN-related antiviral response in vitro and in patients, triggered by the viral RNA and mediated by IFN regulatory factors 3 and 7 and the Janus kinase-signal transducer and activator of transcription cascade; these findings have revealed new insights into HEV-host interactions and provided the basis for understanding the pathogenesis and outcome of HEV infection. (Hepatology 2018;67:2096-2112).
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Wang et al. (2017) studied this question.
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