Understanding the molecular pathogenesis of Ewing sarcoma, specifically EWS-ETS target genes and signaling networks, is crucial for developing new treatment modalities.
May inform targeted Ewing sarcoma therapies; leaves open functional validation and clinical trials.
Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
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Mackintosh et al. (2010) studied this question.
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