Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis

Fig 1. Selection of studies for individual-participant meta-analysis of the association between physical inactivity and dementia and Alzheimer’s disease

Fig 2. Change in hazard ratio for the association between physical inactivity at baseline (year 0) and risk of incident dementia and Alzheimer’s disease over the entire follow-up period (upper panel: follow-up-stratified analysis; lower panel: analysis of flexible parametric proportional-hazards)

Fig 3. Summary hazard ratios from individual-level meta-analysis of 19 cohort studies for the association of physical inactivity with risk of dementia, Alzheimer’s disease, and cardiometabolic disease during the first 10 years of follow-up and from year 10 onwards in those without the disease at year 10

Fig 4. Hazard ratios for the association of physical inactivity with risk of dementia in subgroups from individual-level meta-analysis of 19 cohort studies

Fig 5. Hazard ratios from pooled analysis of 5 cohort studies for a 3-level physical activity in relation to dementia, diabetes, coronary heart disease, and stroke during the first 10 years of follow-up and from year 10 onwards in those without the disease at year 10

Fig 6. Hazard ratios from pooled analysis of 5 cohort studies for the association of physical inactivity with incident dementia with and without preceding incident cardiometabolic disease in participants with no cardiometabolic disease at baseline and no dementia at year 10