Does physical inactivity increase the risk of all-cause dementia or Alzheimer's disease?
Physical inactivity alone is not associated with dementia risk when addressing reverse causation, but may increase risk in those who develop cardiometabolic disease.
In analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer's disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.
Kivimäki et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: