Why the study?
What are the real-world patterns of GDMT titration and discontinuation following heart failure hospitalization, and how do they impact clinical events?
What are the real-world patterns of GDMT titration and discontinuation following heart failure hospitalization, and how do they impact clinical events?
Real-world data demonstrates poor up-titration and early discontinuation of GDMT after heart failure hospitalization, highlighting the urgent need to abandon slow, sequential treatment initiation strategies.
Suboptimal GDMT up-titration and early discontinuation after HF hospitalization persist across countries; leaves open whether targeted strategies improve outcomes.
Despite high risk of clinical events following HHF, new initiation of GDMT was followed by consistent patterns of low up-titration and early GDMT discontinuation in three countries with different health care and economies. Our data highlight the urgent need for moving away from long sequential approach when initiating HF treatment and for improving just-in-time decision support for patients and health care providers.
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Savarese et al. (2021) studied this question.
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