Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study

Six stable and clinically distinct TBI endotypes were identified by probabilistic unsupervised clustering. In addition to presenting neurology, a profile of biochemical derangement was found to be an important distinguishing feature that was both biologically plausible and associated with outcome. Our work motivates refining current TBI classifications with factors describing metabolic stress. Such data-driven clusters suggest TBI endotypes that merit investigation to identify bespoke treatment strategies to improve care. Trial registration The core study was registered with ClinicalTrials. gov, number NCT02210221, registered on August 06, 2014, with Resource Identification Portal (RRID: SCR₀15582).