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hERG roles beyond repolarization merit clinical awareness in drug safety; leaves open extra-cardiac therapeutic targets for prospective study.
To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.
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Babcock et al. (2013) studied this question.
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