Routine coagulation tests like INR and APTT are inadequate for monitoring NOACs, highlighting the need for broader adoption of specific assays.
Supports shift to specific assays for NOAC assessment; leaves open implementation barriers and cost-effectiveness.
The screening tests INR and APTT are suboptimal in assessing NOACs, having high reagent dependence and low sensitivity and specificity. They may provide information, if laboratories recognize their limitations. The variation will likely increase and the sensitivity differ in clinical samples. Specific assays measure NOACs accurately; however, few laboratories applied them.
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Helin et al. (2013) studied this question.
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