Why the study?
Does ageing and oxidative stress aggravate imatinib mesylate cardiotoxicity?
Does ageing and oxidative stress aggravate imatinib mesylate cardiotoxicity?
May worsen imatinib cardiotoxicity with ageing and oxidative stress; leaves open need for enhanced monitoring in older patients.
The results indicate that imatinib action on the heart targets cardiomyocytes and involves mitochondrial impairment and cell death that can be further aggravated by oxidative stress. This in turn offers a possible explanation for the current conflicting data regarding imatinib cardiotoxicity in cancer patients and suggests that cardiac monitoring of older patients receiving imatinib therapy may be especially warranted.
No takes yet. Share an insight, caveat, or question.
Maharsy et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: