What question did this study set out to answer?

To examine whether maternal infection and fever during pregnancy are associated with an increased risk of autism spectrum disorder and other developmental disorders in offspring.

July 17, 2019Autism ResearchOpen Access

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

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Authors

LCLisa CroenKaiser Permanente YQYinge QianKaiser Permanente PAPaul AshwoodUniversity of California Davis Medical Center

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Implication

Case-control study reveals second-trimester maternal infection with fever doubles autism spectrum disorder risk in children, suggesting immune inflammation affects fetal brain development.

Key Points

To examine whether maternal infection and fever during pregnancy are associated with an increased risk of autism spectrum disorder and other developmental disorders in offspring.
Conducted a case-control investigation (Study to Explore Early Development) in children aged 2–5 years classified into autism spectrum disorder (N = 606), other developmental disorders (N = 856), and general population controls (N = 796).
Documented maternal infection and fever history through postnatal telephone interviews and medical record reviews, confirming developmental diagnoses using standardized in-person evaluations.
Maternal infection occurring at any point during pregnancy was not significantly associated with offspring autism spectrum disorder or other developmental disorders following covariate adjustment.
Maternal infection specifically during the second trimester accompanied by fever was associated with a more than twofold increase in the risk of autism spectrum disorder (aOR = 2.19, 95% CI 1.14–4.23).

Cite This Study

Croen et al. (2019) studied this question.

synapsesocial.com/papers/69dcd67a0de68e8319e53b21 https://doi.org/10.1002/aur.2175

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Implication

Case-control study reveals second-trimester maternal infection with fever doubles autism spectrum disorder risk in children, suggesting immune inflammation affects fetal brain development.

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

Discussion

Member takes

Implication

Key Points

Cite This Study

Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development

Discussion

Member takes

Implication

Key Points

Cite This Study

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