Why the study?
Does blocking KCa3.1 suppress plaque instability in advanced stages of atherosclerosis?
Does blocking KCa3.1 suppress plaque instability in advanced stages of atherosclerosis?
Blocking KCa3.1 channels may offer a therapeutic target to stabilize atherosclerotic plaques by modulating macrophage polarization.
May stabilize advanced plaques via macrophage modulation in animals; leaves open clinical translation.
These results suggest that blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.
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Xu et al. (2016) studied this question.
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