Why the study?
How does regional myocardial blood flow relate to segmental shortening in the endocardium and epicardium during ischemia in a canine model?
How does regional myocardial blood flow relate to segmental shortening in the endocardium and epicardium during ischemia in a canine model?
In a canine model of ischemia, endocardial contraction correlates sigmoidally with local blood flow, whereas epicardial contraction is primarily driven by tethering to the endocardium.
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Endocardial metrics may better index ischemia than epicardial in models; leaves open human translation and clinical utility.
Weintraub et al. (1981) studied this question.
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