Why the study?
Does intramuscular injection of bovine eNOS plasmid induce therapeutic angiogenesis in a rat ischemic hindlimb model?
Does intramuscular injection of bovine eNOS plasmid induce therapeutic angiogenesis in a rat ischemic hindlimb model?
Intramuscular injection of bovine eNOS plasmid induces therapeutic angiogenesis in a rat model of hindlimb ischemia, suggesting a potential gene therapy approach for peripheral arterial disease.
Overall, intramuscular injection of bovine eNOS plasmid induced therapeutic angiogenesis in a rat ischemic hindlimb model, a potential therapy for peripheral arterial disease. The stimulation of angiogenesis by NO might be due to upregulation of local VEGF expression.
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Namba et al. (2003) studied this question.
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