Why the study?
Effective stroke prevention with oral anticoagulants is recommended for some patients with AF, but variations in use across geographical regions and types of sites required description.
How does the use and time-to-initiation of oral anticoagulants vary by geographic region and site type in patients with recent-onset atrial fibrillation?
Population
21 237 patients with recent-onset AF across 4 international regions
Comparison
Direct OACs vs vitamin K antagonists vs antiplatelet drugs stratified by region and site type
Design
Prospective observational cohort study (registry)
Authors
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Geographic disparities in post-AF DOAC initiation persist; leaves open regional barriers and equity implications for future trials.
How does the use and time-to-initiation of oral anticoagulants vary by geographic region and site type in patients with recent-onset atrial fibrillation?
There is significant geographic variability in the initiation of oral anticoagulants for patients with recent-onset atrial fibrillation, with lower DOAC initiation rates in Asia and Latin America compared to Europe.
Bayer et al. (2022) studied this question.