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January 18, 2019SHILAP Revista de lepidopterologíaOpen Access

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance

Koutaroh Okada Mitsugu Araki Takuya Sakashita Biao Ma Ryo Kanada Noriko Yanagitani Atsushi Horiike Sumie Koike Tomoko Oh‐hara Kana Watanabe Keiichi Tamai Makoto Maemondo Makoto Nishio Takeshi Ishikawa Yasushi Okuno Naoya Fujita Ryohei Katayama

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Abstract

We discovered lorlatinib-resistant multiple ALK-compound mutations and an L1256F single mutation as well as the potential therapeutic strategies for these ALK mutations. Our original computational simulation to calculate the binding affinity may be applicable for predicting resistant mutations and for overcoming drug resistance in silico. FUND: This work was mainly supported by MEXT/JSPS KAKENHI Grants and AMED Grants.

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Okada et al. (2019) studied this question.

synapsesocial.com/papers/69dd1165d111c0385b359c54 https://doi.org/10.1016/j.ebiom.2019.01.019

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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