Is the cumulative triglyceride glucose-weight adjusted waist index (TyG-WWI) associated with increased cardiovascular disease risk in middle-aged and older individuals?
Cumulative exposure to and changes in the triglyceride glucose-weight adjusted waist index, rather than just baseline levels, are significantly associated with increased cardiovascular disease risk.
Over two survey waves, 613 CVD events were recorded. Analysis using adjusted multivariable models demonstrated a significant relationship between the cumulative TyG-WWI index and increased CVD risk, with an adjusted OR (95% CI) of 1.005 (1.000, 1.009). Class 2 of the TyG-WWI index change showed greater risk of CVD compared to Class 1, with ORs of 1.270 (1.008, 1.605). However, no significant connection was observed between the baseline TyG-WWI index and CVD risk (OR = 1.007, 95% CI: 0.996, 1.019). These findings were corroborated through extensive sensitivity analyses.
Duan et al. (Mon,) studied this question.