AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

Robert J. Fontana; Iris Liou; Adrian Reuben; Ayako Suzuki; M. Isabel Fiel; William M. Lee; Victor J. Navarro

doi:10.1002/hep.32689

July 28, 2022HepatologyOpen Access

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

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Key Points

To provide evidence- and consensus-based clinical practice recommendations for the evaluation, diagnosis, classification, and management of drug, herbal, and dietary supplement-induced liver injury.
Commissioned by the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines Committee to formulate guidance statements using expert panel consensus.
Conducted formal analysis and literature synthesis of observational studies, epidemiologic data, and registry case series in the absence of randomized controlled trials on the topic.
Distinguishes hepatotoxicity into direct, dose-dependent, predictable intrinsic forms (exemplified by acetaminophen) versus dose-independent, unpredictable idiosyncratic reactions.
Identifies herbal and dietary supplements alongside prescription drugs as leading drivers of toxic hepatitis, underscoring that definitive diagnosis requires systematic exclusion of competing liver diseases.
Recommends immediate cessation of suspect agents, careful risk assessment for progressive acute liver failure, and selective application of liver biopsy when diagnostic ambiguity persists.

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Implication

Practice guidance reveals diagnostic pathways and risk stratification for toxic hepatotoxicity in patients taking medications or supplements, highlighting prompt agent withdrawal to prevent organ...

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Fontana et al. (2022) studied this question.

synapsesocial.com/papers/69dd1c2a61d4dd8dbb1334d9 https://doi.org/10.1002/hep.32689

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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

Key Points

No abstract yet

Implication

Discussion

Cite This Study

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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