March 1, 2002Journal of Applied Physiology
Computational modeling of cardiovascular response to orthostatic stress
Population
Computational model of the cardiovascular system consisting of a closed-loop lumped-parameter representation…
Comparison
Simulation of short-term transient and… vs Population-averaged hemodynamic data reported in…
Design
Other
Authors
Discussion
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Member takes
Implication
Supports orthostatic hemodynamics modeling; leaves open clinical translation pending prospective validation.
Structured PICO
P
Population
Computational model of the cardiovascular system consisting of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes
I
Intervention
Simulation of short-term (<= 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure
C
Comparator
Population-averaged hemodynamic data reported in the literature
O
Outcome
Simulation output under baseline conditions and at different levels of orthostatic stress compared to experimental datasurrogate
A computational model of the cardiovascular system successfully simulated hemodynamic responses to orthostatic stress, matching experimental data.
Cite This Study
Heldt et al. (2002) studied this question.