Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance
Why the study?
Are higher oxidized LDL levels associated with metabolic syndrome independently of central obesity and insulin resistance in subjects without diabetes?
Population
n=3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study
Comparison
Higher oxidized LDL levels vs Lowest oxidized LDL (ox-LDL) level (quartile 1)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
ox-LDL was associated with metabolic syndrome beyond obesity and insulin resistance; leaves open predictive value and clinical utility.
Structured PICO
Are higher oxidized LDL levels associated with metabolic syndrome independently of central obesity and insulin resistance in subjects without diabetes?
P
Population
n=3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study
I
Intervention
Higher oxidized LDL (ox-LDL) levels (quartiles 2, 3, and 4)
C
Comparator
Lowest oxidized LDL (ox-LDL) level (quartile 1)
O
Outcome
Metabolic syndrome (MS)surrogate
Higher oxidized LDL concentrations are associated with metabolic syndrome independently of central obesity and insulin resistance, suggesting ox-LDL may be a clinically relevant predictor of metabolic syndrome development.
Cite This Study
Hurtado-Roca et al. (2016) studied this question.