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February 18, 2014Respiratory ResearchOpen Access

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells

Kazuaki Nomura Kazufumi Obata Takashi Keira Ryo Miyata Satoshi Hirakawa Kenichi Takano Takayuki Kohno Norimasa Sawada Tetsuo Himi Takashi Kojima

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Abstract

PE transiently disrupts tight junctions in HNECs and downregulates PAR-2. The transient disruption of tight junctions by PE might occur repeatedly during chronic rhinosinusitis.

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Nomura et al. (2014) studied this question.

synapsesocial.com/papers/69dd2d3d656f15f1fc100e15 https://doi.org/10.1186/1465-9921-15-21

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Pseudomonas aeruginosa Elastase Disables Proteinase-Activated Receptor 2 in Respiratory Epithelial CellsOriginal Research · 2005 · 139 citations
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