Why the study?
Does smoking increase tissue factor expression and thrombogenicity in atherosclerotic plaques?
Does smoking increase tissue factor expression and thrombogenicity in atherosclerotic plaques?
Increased plaque tissue factor expression provides a mechanistic explanation for higher atherothrombotic risk in smokers, which may be mitigated by aspirin.
May explain smoking-related thrombosis via TF; hypothesis-generating for aspirin effects on plaque expression.
Our results suggest increased plaque TF expression and thrombogenicity as a novel mechanism for the increased risk of atherothrombotic events in smokers. Treatment with aspirin may reduce TF expression.
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Matetzky et al. (2000) studied this question.
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