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May 21, 2025Cardiovascular Diabetology24 citationsOpen Access

Cardiovascular risk profile in subjects with diabetes: Is SCORE2-Diabetes reliable?

SSSabrina ScillettaMMMaurizio Di MarcoNMNicoletta Miano

Structured PICO

Does SCORE2-Diabetes improve the identification of preclinical vascular damage compared to SCORE2 in T2D patients without ASCVD or TOD?

P
Population
Patients with Type 2 Diabetes (T2D) without atherosclerotic cardiovascular disease (ASCVD) or target organ damage (TOD)
I
Intervention
Risk stratification using SCORE2-Diabetes
C
Comparator
Risk stratification using SCORE2
O
Outcome
Preclinical vascular damage (measured by pulse wave velocity [PWV], intima-media thickness [IMT], and carotid atherosclerosis prevalence)surrogate

SCORE2-Diabetes is a reliable tool for identifying preclinical vascular damage in T2D patients without established ASCVD or target organ damage, outperforming the standard SCORE2.

Abstract

Higher PWV, IMT, and carotid atherosclerosis prevalence were associated with increasing CV risk stratified by SCORE2-Diabetes, with no significant differences between the very high and ASCVD/TOD groups. SCORE2-Diabetes demonstrated a better identification of preclinical vascular damage compared to SCORE2, supporting its use as a reliable tool for identifying vascular damage in T2D patients without ASCVD or TOD.

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Cite This Study

Scilletta et al. (2025) studied this question.

synapsesocial.com/papers/69dd4011fb7610310c10149dhttps://doi.org/10.1186/s12933-025-02769-7
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