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January 19, 2012SHILAP Revista de lepidopterología200 citationsOpen Access

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

LGLuciana Rodrigues GomesLTLetícia Ferreira TerraRWRosangela A.M. Wailemann

Key Points

  • To determine how TGF-β1 modulates the balance between matrix metalloproteinases and their endogenous inhibitors in invasive breast cancer cells.
  • Assessed mRNA and protein expression profiles of MMPs (MMP-2 and MMP-9) and their inhibitors (TIMP-2 and RECK) in invasive breast cancer cell models.
  • Evaluated the regulatory role of TGF-β1 signaling through the p38 MAPK and ERK1/2 pathways.
  • TGF-β1 modulated the mRNA and protein expression of MMP-2 and MMP-9 in parallel with their endogenous inhibitors TIMP-2 and RECK.
  • Modulation of these ECM regulators disrupted extracellular matrix homeostasis, highlighting TGF-β1 as a key mediator of breast cancer progression.

Abstract

Altogether, our results support that TGF-β1 modulates the mRNA and protein levels of MMPs (MMP-2 and MMP-9) as much as their inhibitors (TIMP-2 and RECK). Therefore, this cytokine plays a crucial role in breast cancer progression by modulating key elements of ECM homeostasis control. Thus, although the complexity of this signaling network, TGF-β1 still remains a promising target for breast cancer treatment.

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Cite This Study

Gomes et al. (2012) studied this question.

synapsesocial.com/papers/69dd404527c48be1bb40c79chttps://doi.org/10.1186/1471-2407-12-26
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