What question did this study set out to answer?

Determine reference rates for dissecting abdominal aortic aneurysm incidence and mortality in angiotensin II-infused mouse models while identifying confounding factors.

August 24, 2015Cardiovascular ResearchOpen Access

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

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Determine reference rates for dissecting abdominal aortic aneurysm incidence and mortality in angiotensin II-infused mouse models while identifying confounding factors.
Conducted a systematic review and meta-analysis of preclinical animal studies utilizing angiotensin II infusion to induce dissecting abdominal aortic aneurysms in mice.
Assessed reported outcomes including aneurysm incidence, disease severity, rupture mortality, and confounding variables across studies.
Provides pooled reference benchmarks for the incidence and mortality of dissecting abdominal aortic aneurysms in the angiotensin II mouse model.
Identified significant confounding factors in aneurysm detection, demonstrating that preclinical therapeutic efficacy studies using this model require cautious interpretation.

Structured PICO

Population

angiotensin II-infused mice

Outcome

incidence, severity, and mortality of dissecting abdominal aortic aneurysm (AAA)hard clinical

Treatment studies using the angiotensin II-infused mouse model for dissecting abdominal aortic aneurysm should be interpreted with caution.

Implication

Warrants caution interpreting treatment effects in the Ang II mouse AAA model; challenges its reliability for preclinical research.

Abstract

Our data provide a new meta-analysis-based reference for incidence and mortality of dissecting AAA in angiotensin II-infused mice, and indicate that treatment studies using this mouse model should be interpreted with caution.

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Cite This Study

Trachet et al. (2015) studied this question.

synapsesocial.com/papers/69dd427a0a7b4bc8c41010f3 https://doi.org/10.1093/cvr/cvv215

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Implication

Warrants caution interpreting treatment effects in the Ang II mouse AAA model; challenges its reliability for preclinical research.

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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