Why the study?
Is serum EC-SOD concentration associated with the severity of vascular complications in patients with Type 2 Diabetes?
Is serum EC-SOD concentration associated with the severity of vascular complications in patients with Type 2 Diabetes?
Serum EC-SOD concentration may serve as a marker of vascular injury in patients with type 2 diabetes.
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Serum EC-SOD may mark vascular injury severity in type 2 diabetes; leaves open its prognostic value and clinical utility pending prospective studies.
We observed a strong relationship between the serum concentration of EC-SOD and the severity of both micro- and macrovascular diabetic complications. These findings suggest that serum EC-SOD concentration levels may be a marker of vascular injury, possibly reflecting hyperglycemia-induced oxidative injury to the vascular endothelium and decreased binding of EC-SOD to the vascular wall.
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Kimura et al. (2003) studied this question.
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