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Research Paper | Synapse

September 2, 2022Open Access

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

BZBing ZhuTongji University YLYan LiuCarrier (United States)SHSpring HwangThe University of Texas MD Anderson Cancer Center

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Resumen

Together, our results reveal a role for Trem2 in suppressing exosomal tau pathogenicity, and demonstrates that Trem2 deletion can enhance tau trafficking, distribution and seeding through microglial exosomes.

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Cite This Study

Zhu et al. (Fri,) studied this question.

synapsesocial.com/papers/69dd49050644c7b49d40ca32 https://doi.org/https://doi.org/10.1186/s13024-022-00562-8

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5Depletion of microglia and inhibition of exosome synthesis halt tau propagation2015 · 1,622 citations