Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.
No takes yet. Share an insight, caveat, or question.
Henry M. Sobell (1985) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: