Head-to-head comparison of MASH resolution index versus FAST for noninvasive prediction of resolution of MASH on biopsy

Rohit Loomba; Peter C. Daniel; Maral Amangurbanova; Ricki Bettencourt; Egbert Madamba; Harris Siddiqi; Lisa Richards; Mildred D. Gottwald; Shibao Feng; Maya Margalit; Daniel Q. Huang

doi:10.1097/hep.0000000000001396

May 9, 2025Hepatology

Head-to-head comparison of MASH resolution index versus FAST for noninvasive prediction of resolution of MASH on biopsy

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Key Points

Compare the diagnostic performance of the MASH resolution index against the FAST score for the noninvasive prediction of biopsy-confirmed MASH resolution.
Conducted a head-to-head comparative analysis assessing the predictive utility of the MASH resolution index (MASHResInd) against the FAST score.
Used histological assessment via liver biopsy as the reference standard to evaluate the resolution of MASH.
MASHResInd showed superior diagnostic capability compared with the FAST score in noninvasively predicting the resolution of MASH.

Implication

Comparative study reveals MASH resolution index outperforms FAST score in predicting steatohepatitis resolution, highlighting its utility for noninvasive monitoring in clinical trials.

Abstract

The MASHResInd is better than the FAST score in the noninvasive prediction of MASH resolution. These data may have implications for clinical practice and trials.

Discussion

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Cite This Study

Loomba et al. (2025) studied this question.

synapsesocial.com/papers/69dd4b0f7808b00a4799c402 https://doi.org/10.1097/hep.0000000000001396

View at Publisher

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Head-to-head comparison of MASH resolution index versus FAST for noninvasive prediction of resolution of MASH on biopsy

Key Points

Implication

Abstract

Discussion

Cite This Study

Head-to-head comparison of MASH resolution index versus FAST for noninvasive prediction of resolution of MASH on biopsy

Key Points

Implication

Abstract

Discussion

Cite This Study

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