The predominance of genotype P[4]G2 rotavirus in a highly vaccinated population suggests the vaccine may be less protective against this specific strain.
Warrants continued rotavirus genotype surveillance in vaccinated populations; leaves open whether current vaccines need strain updates.
We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2. Prospective surveillance is urgently needed.
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Gurgel et al. (2007) studied this question.
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