Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2019ViewOpen Access

Clinical use of TIMP-2•IGFBP7 biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does [TIMP-2]•[IGFBP7] biomarker testing improve the management of acute kidney injury risk in critical care patients?

Design

Expert panel guidance

Authors

LGLouis M. GuzziOrlando Regional Medical CenterTBTobias BerglerUniversity Hospital RegensburgBBBrian BinnallBaystate Medical Center

Discussion

Loading...

Member takes

Implication

Supports biomarker-guided AKI management in critical care; extends consensus with actionable risk-stratification protocols.

Structured PICO

Does [TIMP-2]•[IGFBP7] biomarker testing improve the management of acute kidney injury risk in critical care patients?

P
Population
Critical care patients after major surgery, hemodynamic instability, or sepsis
I
Intervention
[TIMP-2]•[IGFBP7] biomarker testing
O
Outcome
Risk of acute kidney injury and subsequent clinical management (management of nephrotoxic drugs and fluids, or eligibility for fast-track protocols)

[TIMP-2]•[IGFBP7] biomarker testing can guide clinical management in critical care by identifying patients who need nephrotoxic drug and fluid management versus those suitable for fast-track protocols.

Cite This Study

Guzzi et al. (2019) studied this question.

synapsesocial.com/papers/69dd4d4027c48be1bb40cc13https://doi.org/10.1186/s13054-019-2504-8
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Urinary TIMP-2 and IGFBP7 for the prediction of acute kidney injury following cardiac surgery2017 · 82 citations
  2. 2Kinetics of Urinary Cell Cycle Arrest Markers for Acute Kidney Injury Following Exposure to Potential Renal Insults2017 · 77 citations
  3. 3The diagnostic accuracy of urinary [TIMP-2]·[IGFBP7] for acute kidney injury in adults2017 · 58 citations
  4. 4Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?2015 · 107 citations
  5. 5Diagnostic Value of Urine Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Acute Kidney Injury: A Meta-Analysis2017 · 29 citations