Answers are grounded in this paper and cite their sources.
Retrospective comparative effectiveness study reveals distinct outcomes for esketamine with SSRIs versus SNRIs in depression, highlighting differing effects on relapse and suicide risk.
In this retrospective comparative effectiveness study, among the study sample, incidence of mortality, hospitalizations, depressive relapses, and suicide attempts was low. The esketamine + SNRI group showed lower incidence of mortality, hospitalizations, and depressive relapses, while the esketamine + SSRI group showed a slightly lower incidence of suicidal attempts.
No takes yet. Share an insight, caveat, or question.
Casale et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: