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January 1, 2010Platelets

The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets

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Why the study?

Does P2Y receptor antagonism prevent ADP-mediated release of VEGF and endostatin from platelets?

Population

Minimally altered whole blood (WB) and platelet rich plasma (PRP) from healthy volunteers

Comparison

ADP alone or in combination with a P2Y… vs Control

Design

Preclinical

Authors

NBNadia M. BambaceBaptist Hospital of MiamiJLJamie E. LevisUniversity of VermontCHChris E. HolmesUniversity of Vermont

Discussion

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Implication

P2Y antagonism may limit platelet angiogenesis in vitro; animal data leave open in vivo or clinical relevance.

Structured PICO

Does P2Y receptor antagonism prevent ADP-mediated release of VEGF and endostatin from platelets?

P
Population
Minimally altered whole blood (WB) and platelet rich plasma (PRP) from healthy volunteers
I
Intervention
ADP (12.5 uM) alone or in combination with a P2Y(1) antagonist (MRS2179) or a P2Y(12) antagonist (cangrelor)
C
Comparator
Control
O
Outcome
VEGF and endostatin protein concentrations assessed by ELISAsurrogate

P2Y receptor antagonism abrogates ADP-mediated proangiogenic VEGF release from platelets, highlighting a potential mechanism for regulating platelet-mediated angiogenesis.

Cite This Study

Bambace et al. (2010) studied this question.

synapsesocial.com/papers/69dd527efb7610310c10217fhttps://doi.org/10.3109/09537100903470298
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin1999 · 851 citations
  2. 2Activated human platelets release connective tissue growth factor2004 · 72 citations
  3. 3Platelets From a Patient Heterozygous for the Defect of P2 CYC Receptors for ADP Have a Secretion Defect Despite Normal Thromboxane A 2 Production and Normal Granule Stores2000 · 139 citations