Does simulation of multiple ion channel block improve early prediction of compounds' clinical torsadogenic risk compared to hERG block effect alone?
Simulating multiple ion channel block provides a more reliable early prediction of a compound's torsadogenic risk than relying on hERG block alone.
The suggested calculations improve the reliability of early cardiac safety assessments, beyond those based solely on a hERG block effect.
Mirams et al. (Mon,) studied this question.