Why the study?
Does simulation of multiple ion channel block improve early prediction of compounds' clinical torsadogenic risk compared to hERG block effect alone?
Population
Compounds assessed for clinical torsadogenic risk
Comparison
Simulation of multiple ion channel block vs Assessments based solely on a hERG block effect
Design
Preclinical
Authors
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May improve preclinical cardiac safety screening; hypothesis-generating for clinical torsadogenic risk prediction pending validation.
Does simulation of multiple ion channel block improve early prediction of compounds' clinical torsadogenic risk compared to hERG block effect alone?
Simulating multiple ion channel block provides a more reliable early prediction of a compound's torsadogenic risk than relying on hERG block alone.
Mirams et al. (2011) studied this question.
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