The kinetics of the I(Ks) current in human ventricular myocytes differ from guinea pig models and more closely resemble those of dogs and rabbits, which has implications for selecting appropriate animal models in cardiac electrophysiology research.
In undiseased human ventricular myocytes, I(Ks) exhibits slow activation and fast deactivation kinetics. Therefore, in humans I(Ks) differs from that reported in guinea pig, and it best resembles I(Ks) described in dog and rabbit ventricular myocytes.
László Virág (Thu,) studied this question.